When CBD is smoked or vaped, cannabinoids are sent directly to the lungs and are rapidly absorbed into the bloodstream and put into circulation throughout the body. It reaches peak concentrations in plasma within 3 minutes of consumption. A 2007 study states that CBD can be detected up to 72 hours after smoking.
5 milligrams of THC and 1. 35 milligrams of CBD. The research team found that CBD was only detectable in the blood for up to 6 hours after ingestion. There is mounting research on CBD's potential medical benefits, including scientific evidence for its effectiveness in the treatment of epilepsy by reducing seizures.
While some consumers and patients prefer to take their CBD through oral administration or topical application, others have found inhalation to be the most effective consumption method. Many consumers typically prefer consuming or smoking CBD through a pipe, joint, or a vape pen (CBD). Photo by: Gina Coleman/Weedmaps Many consumers typically prefer consuming or smoking CBD through a pipe, joint, or a vape pen.
To be high, or not to be high? That is a question that may appeal as the easiest illustrate the difference between smoking high-CBD flower and THC-heavy flower. But it's a bit more complex than that. Tetrahydrocannabinol (THC) and CBD are the most prevalent among the 113 identified cannabinoids in cannabis plants.
CBD is often touted as “non-psychoactive,” however this statement is somewhat misleading — and a more accurate way to describe CBD is as a non-intoxicating substance. Any substance that has a direct effect on the function of the brain, which CBD does to a certain extent, is considered to be psychoactive.
Photo by: Gina Coleman/Weedmaps Both THC and CBD interact with the body's endocannabinoid system (ECS). The endocannabinoid system is a group of cannabinoid receptors found throughout the body. These receptors are located in the central nervous system, the peripheral nervous system, and the immune system. THC binds with the CB1 receptors in the brain to produce a high, while CBD has shown to have the opposite interaction with CB1 receptors, acting as an antagonist.
In other words, CBD, which can be extracted from either the marijuana or hemp plant, is a non-intoxicating compound, meaning it does not produce a high when used by itself or in tandem with other non-intoxicating compounds. While more research into the effectiveness of CBD consumption methods is needed, most evidence suggests that vaping or smoking CBD itself will not cause intoxicating side effects.
It's important to note that the act of smoking cannabis, even high-CBD strains, could potentially lead to respiratory issues. A 2007 study published in the Harm Reduction Journal examined self-reported respiratory symptoms in participants who used cigarettes and cannabis, and discovered that using a vaporizer could decrease respiratory symptoms in regular cannabis users who smoke.
Photo by: Gina Coleman/Weedmaps An often-cited study in the Journal of the American Medical Association, published in 2017, found a disturbingly wide range of CBD concentrations when testing products purchased online. Of the products tested in the study, 26% contained less CBD than labeled, which could negate any potential positive clinical response, according to the study.
A patient in Illinois on Aug. 23, 2019, became the first known to die of a mysterious lung illness linked to vaping. The death occurred as doctors and hospitals nationwide are reporting an increasing number of vaping-related respiratory illnesses over summer, with 193 reported in 22 states, the New York Times reported.
When medications are administered in ways other than intravenously, the bioavailability rate naturally drops. This is due to incomplete absorption and what's known as first-pass metabolism — when the concentration of a drug is reduced before it reaches the circulatory system. Smoking has been shown to increase absorption. One study, Human Cannabinoid Pharmacokinetics published in 2017, states that “smoking provides a rapid and efficient method of drug delivery,” although the bioavailability can vary broadly based on how the CBD is smoked (duration, spacing of puffs, hold time, and inhalation volume).
It reaches peak concentrations in plasma within 3 minutes after consumption, meaning the effects can be felt almost directly after use. When smoking or vaping CBD, the cannabinoids are sent directly to the lungs before being rapidly absorbed into the bloodstream and put into circulation throughout the body. Photo by: Gina Coleman/Weedmaps With ingestion, CBD is first sent through the digestive tract and metabolized in the liver, where it is broken down before finally being sent into the bloodstream.